Brief overview of Ligandrol (LGD4033)

• Ligandrol (LGD4033) It is one of the most powerful SARMs for increasing muscle mass and strength, and is particularly recommended for bulking cycles.
• It causes a suppression of endogenous testosterone more pronounced than with other SARMs.

• It can promote a certain intramuscular water retention , giving it a fuller, more swollen appearance.

• Like other SARMs, LGD4033 It can affect the lipid profile and, in some individuals, increase liver enzymes.

What Is Ligandrol (LGD4033)?

Ligandrol, also known as LGD4033, is one of the most studied and widely used SARMs, having already undergone several clinical trials in humans and having been included in the Phase 2 of the clinical trial

LGD4033 was developed by Ligand Pharmaceuticals for the treatment of conditions associated with muscle loss, such as cancer and AIDS. It is a Second-generation SARMs, which is more advanced than first-generation compounds such as S4 (Andarine). To date, Ligandrol is the the second most-studied SARM after Ostarina.

From an anabolic standpoint, LGD4033 is considered the most effective of the SARMs for muscle growth, but it is also the one with the greatest impact on the suppression of natural testosterone. A significant advantage of Ligandrol is its long half-life (24–36 hours), which maintains a stable plasma concentration with a single daily dose.

Main effects of LGD4033

• Significant increase in muscle mass, often accompanied by moderate fluid retention
• A marked increase in strength, making it one of the most powerful SARMs ever

• Increase in bone mineral density

• Decrease in SHBG (sex hormone-binding globulin), resulting in an increase in biologically active free testosterone

Testosterone suppression

Ligandrol (LGD4033) It is the SARM that it further suppresses endogenous testosterone production. In many users, symptoms of low testosterone (decreased libido, fatigue) may appear as early as around fourth week of the cycle, especially at medium-to-high doses.

The deletion is dose-dependent. Clinical studies have shown that, after 21 days of using LGD4033, hormone levels return to baseline within approximately 56 days, making A PCT is required

To limit the drop in testosterone, the following are commonly used during or after the cycle: SERM (such as clomiphene or tamoxifen) or hormonal support strategies using testosterone or gonadotropin, depending on the user’s experience.

Effects on the liver

The use of LGD4033 may lead to an increase in liver enzymes ALT and AST. For this reason, it is recommended to support liver function with supplements such as:

• NAC : 600–1,200 mg

• TUDCA: up to 500 mg

• ALA : about 500 mg

Change in lipid profile

Like all SARMs, Ligandrol may alter the lipid profile, possibly by lowering HDL (good cholesterol) and increasing LDL (bad cholesterol). During a course of LGD4033, it is strongly recommended to monitor blood levels.

Pharmacokinetic profile

• Half-life : 24–36 hours

Recommended dosages

• Beginners : 5–10 mg per day

• Average dosage: 10–30 mg per day
• Recommended maximum: 40 mg per day

• Women : up to 5 mg per day