Brief overview of Testolone (RAD140)

Few compounds match its potency. Testolone (RAD140) remains one of the strongest SARMs you can find. It promotes solid muscle mass and strength gains. The result is a firm, dense, and vascularized appearance. Athletes notice physical changes. They report increased muscle stiffness and a constant feeling of fullness.

Compared to milder SARMs such as Ostarina or Andarine, the integration of rad140 causes greater suppression of endogenous testosterone. It offers a protective effect on the prostate, which helps when combined with anabolic-androgenic steroids.
Experimental studies indicate a positive effect in reducing breast cancer, and testolone rad 140 remains a subject of clinical interest.

What is Testolone (RAD140)?

RAD140, also known as big testicle, is a selective androgen receptor modulator developed by Radius Pharmaceuticals in the late 2000s. It was designed as a potential treatment for muscle loss (sarcopenia) and subsequently studied in the context of breast cancer.

rad140 matches LGD-4033 anabolic action. It acts as a partial agonist in prostate tissue to lower hyperplasia risk.

Another advantage is the improvement in lipid profile (including LDL, HDL, and triglycerides) without an increase in liver enzymes in most users.

Scientific research on RAD140

RAD140 is an experimental SARM developed by Radius Health Inc. for androgen replacement therapy. In 2020, it was licensed to Ellipses Pharmaceuticals.
Preclinical animal studies have shown that big testicle can increase lean muscle mass and bone density with a safety profile potentially superior to traditional testosterone.

The first clinical trial in humans began in 2017 and concluded in 2020, involving postmenopausal women with breast cancer.

Main effects of RAD140 (Testolone)

• Notable increase in muscle mass

• A marked increase in strength, which is often greater than muscle growth itself

• Reduction of body fat

• Increase in bone mineral density

• Prostate Protection thanks to partial agonism at androgen receptors

• Activity on androgen receptors in breast cancer cells, with gene repression ESR1

Effect on the liver

Anecdotal evidence and blood tests conducted on athletes suggest that rad140 is not hepatotoxic in most cases. As a precaution, athletes schedule blood tests (ALT, AST) before and after the treatment cycle.
Only one case of liver dysfunction was reported during a clinical trial, and the cause has not yet been fully determined.

Lipid profile

Like all SARMs, this big testicle may affect blood lipids, potentially leading to a decrease in HDL and an increase in LDL. It is recommended to monitor cholesterol levels during the treatment cycle.

Testosterone suppression

Doses of ≥10 mg change hormone levels. Testosterone suppression with RAD140 tends to occur between Weeks 6 and 7. Some users take higher doses (20–30 mg). Under those amounts, suppression may occur sooner. To lower this risk, many people choose a strict daily limit. They take no more than 10 mg per day.

Half-life

• About 60 hours

RAD140 dosages

• Beginners: 5–10 mg per day

• Average dosage: 10–20 mg per day

• Recommended maximum: 30 mg per day

• Women: 5–10 mg per day