Description of the drug

Aromasin is the trade name of theex-semester, a powerful third-generation aromatase inhibitor (inactivator), a nonsteroidal and highly selective drug. This drug was originally developed as an antineoplastic agent and is widely used in the treatment of estrogen-dependent breast cancers

In men’s competition, theex-semester is used for reduce estrogen levels in the blood and promote an increase in the endogenous testosterone and gonadotropin hormones. The mechanism is based on the inhibition of the enzyme aromatase, which is responsible for converting testosterone into estrogen. An excess of estrogen can, in fact, have adverse effects on the central nervous system and the hypothalamic-pituitary-gonadal axis, reducing LH secretion and, consequently, testosterone production.

It is important to emphasize that Aromasin (exemestane) Durabolin It does not directly lower already elevated estradiol levels, but prevents the formation of new estrogens, helping to stabilize hormonal balance.

Mechanism of action

Theexemestane 25 mg belongs to the third-generation aromatase inhibitors. During the first oxidation cycle, the drug creates a irreversible covalent bond with the enzyme aromatase, leading to its selective inactivation.

This mechanism allows:

• one a reduction in estrogen synthesis of up to 97%

• superior efficacy compared to other inhibitors such as anastrozole

• one better tolerability and a lower incidence of side effects

Pharmacokinetic profile

• Half-life: about 24 hours

• Frequency of use: once every 1–3 days

Main effects

• prevention of gynecomastia

• increase in levels of anabolic hormones in the blood

• improvement of the muscle definition (by reducing the negative effects of estrogen)

• support for the prevention ofestrogen-related hypertension

• reduction in estrogen-mediated suppression of the hypothalamic-pituitary-testicular axis, promoting a faster hormonal recovery

Possible side effects

• possible inhibition of muscle growth if estrogen levels are suppressed excessively

• arthralgia (joint pain)

• reduction in bone density

• changes in the lipid profile (high cholesterol)

• decreased libido

• deterioration in overall well-being

• depressive symptoms

Storage

• keep out of reach of children

• store in a cool, dry place

• protect from direct sunlight

• store at room temperature

• Do not use after the expiration date.