HCG – Human Chorionic Gonadotropin

HCG – Human Chorionic Gonadotropin
Composition: human chorionic gonadotropin (HCG) 5,000 IU.
Category: Peptide, hormonal support during and after the menstrual cycle.
Purpose: to stimulate gonadal activity, maintain endogenous testosterone production, and support the recovery of reproductive function.
Form: vial containing lyophilized powder + 1-ml vial of water for injection for reconstitution.
Administration: subcutaneous injection.

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What is it? hCG (Gonase)

The human chorionic gonadotropin, commonly referred to as hCG and also marketed as Gonase, is a peptide hormone produced naturally during pregnancy. In sports and clinical settings, it is used to maintain and restore the body’s natural production of testosterone when the hypothalamic-pituitary-adrenal axis is suppressed, for example during courses of anabolic-androgenic steroids (AAS).

ThehCG/Gonasemimics luteinizing hormone (LH), by binding to its receptors in Leydig cells and stimulating testosterone synthesis. In medicine, it was initially used to induce ovulation in women and support spermatogenesis and fertility in men; it later became a mainstay of hormonal support for athletes.

Main effects of hCG (Gonase)

📈 Maintains and increases endogenous testosterone during AAS withdrawal
🧬 Supports fertility and libido
⚙️ Preserves testicular volume and function, preventing atrophy
🔁 Helps maintain hormonal balance during extended cycles

How to take hCG (Gonase)

Before use, ask for instructions on Reconstitution and Injection Technique . hCG is particularly recommended for cycles longer than 6 weeks

Typical diagram

Scope	Dosage	Frequency	Duration
During AAS cycle (from week 4)	~1000 IU/week (750–1250 IU)	2 injections of 500 IU	Until the end of the cycle
Libido/energy support	500 IU	1–2 times a week	2–4 weeks

📌 Monitor: total/free testosterone, LH, FSH, estradiol, prolactin; in long cycles, also β-hCG

Precautions

Do not associate SERM (clomiphene, tamoxifen) during the use of hCG; reserve them for PCT
Avoid combining with other gonadotropins or LH mimetics.
Watch for signs of excess estrogen (edema, nipple tenderness).
Use moderate amounts to prevent desensitization of LH receptors.

Possible side effects

Increased estrogen (with overdose)
Testicular tenderness or swelling
Mood swings, fatigue

Storage

Refrigerator 2–8 °C , away from light and heat
After reconstitution: 1–2 months if stored properly

How hCG (Gonase) works

ThehCG It is a “functional duplicate of LH”: maintains the intratesticular testosterone (ITT) and gonadal function even when the HPG axis is suppressed by AAS. For this reason, it is ideal during your period, while in PCT It is preferable to reactivate the upper branch (hypothalamus/pituitary gland) using the SERM

Clinical studies (Coviello 2005; Roth 2010–2011) show that low–moderate doses hCG levels maintain ITT at near-physiological levels with a response dose-dependent up to a certain threshold, confirming the importance of avoiding excesses.

Quick FAQs

When should I start? Around the Week 4 of the AAS cycle.
During PCT? No, stop taking it first and switch to SERMs.
Fat loss? Indirectly, yes—by supporting testosterone levels, energy, and lean body mass.